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Side Effects, Dosage, Uses & More

FDA warning: Suicidal thoughts or behavior warning

  • This drug has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients about drug effects that may be dangerous.
  • This drug may increase suicidal thoughts or behavior in some children, teenagers, or young adults. The risk of this is greatest within the first few months of treatment or when the dosage is changed. Call your healthcare provider right away if you have new or sudden changes in your mood, behavior, actions, thoughts, or feelings, especially if they are severe. Pay extra close attention when you start taking this drug or when your dosage is changed.
  • Serotonin syndrome: This drug may cause a possibly life-threatening condition called serotonin syndrome. The symptoms of serotonin syndrome include hallucinations and delusions, agitation, coma, fast heart rate, and changes in blood pressure. They also include dizziness, loss of consciousness, seizures, shakiness, muscle tremor or stiff muscles, sweating, nausea, and vomiting.
  • Severe allergic reaction: This drug can sometimes cause a severe allergic reaction. Call 911 or go to the emergency room right away if you have swelling of your face, tongue, or throat, or you have trouble breathing. A severe allergic reaction may cause death. You should not take this medication again if you have ever had an allergic reaction to it.

Sertraline oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. This drug is also available as an oral solution.

Why it’s used

This drug is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder.

  Benefits, Side Effects, and More

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

How it works

This drug belongs to a class of drugs called selective serotonin reuptake inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

This drug works by increasing the amount of serotonin, a natural substance in your brain, that helps maintain mental health balance. This can improve the symptoms of depression and anxiety.

Sertraline oral tablet may cause drowsiness, insomnia, or both. It may also cause other side effects.

More common side effects

The adult side effects for this drug are slightly different from the side effects for children. Side effects for adults and children can include:

  • nausea, loss of appetite, diarrhea, and indigestion
  • change in sleep habits, including increased sleepiness and insomnia
  • increased sweating
  • sexual problems, including decreased sex drive and ejaculation failure
  • tremor or shaking
  • tiredness and fatigue
  • agitation

Additional side effects for children can include:

  • abnormal increase in muscle movement or agitation
  • nose bleed
  • more frequent urination
  • urine leakage
  • aggressiveness
  • heavy menstrual periods
  • slowed growth rate and weight change. You should closely watch your child’s height and weight while they take this drug.

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Suicide attempts
  • Acting on dangerous impulses
  • Aggressive or violent behavior
  • Thoughts about suicide or dying
  • New or worse depression
  • New or worse anxiety or panic attacks
  • Agitation, restlessness, anger, or irritability
  • Trouble sleeping
  • An increase in activity or talking more than normal
  • Serotonin syndrome. This condition can be life-threatening. Symptoms can include:
    • hallucinations and delusions
    • agitation
    • loss of consciousness
    • seizures
    • coma
    • fast heart rate
    • changes in blood pressure
    • muscle tremor or stiff muscles
    • dizziness
    • shakiness
    • sweating
    • nausea
    • vomiting
    • muscle rigidity
  • Severe allergic reactions. Symptoms can include:
    • trouble breathing
    • swelling of your face, tongue, eyes, or mouth
    • rash, itchy welts (hives) or blisters, alone or with fever or joint pain
  • Abnormal bleeding
  • Seizures or convulsions
  • Manic episodes. Symptoms can include:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • talking more or faster than usual
  • Changes in appetite or weight. You should check the weight and height of children and adolescents often while they take this drug.
  • Low sodium levels. Seniors may be at greater risk for this. Symptoms can include:
    • headache
    • weakness or unsteadiness
    • confusion, problems concentrating or thinking, or memory problems
  • Eye pain
  • Changes in vision, including blurred and double vision
  • Swelling or redness in or around your eyes
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Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical…

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